Journal article
Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues
S Siva, P Lobachevsky, MP MacManus, T Kron, A Möller, RJ Lobb, J Ventura, N Best, J Smith, D Ball, OA Martin
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2016
Abstract
Purpose: To study the response of irradiated and out-of-field normal tissues during localized curative intent radiotherapy. Experimental Design: Sixteen patients withnon-small cell lung carcinoma (NSCLC) received 60 Gy in 30 fractions of definitive thoracic radiotherapy with or without concurrent chemotherapy. Peripheral blood lymphocytes (PBL) and eyebrow hairs were sampled prior, during, and after radiotherapy. Clinical variables of radiotherapydose/volume,patient age,anduse ofchemoradiotherapy were tested for association with γ-H2AX foci, a biomarker of DNA damage that underlies cellular response to irradiation. Results: Radiotherapy induced an elevation of γ-H2AX foci in PBL, representin..
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Funding Acknowledgements
This study was supported by the Australian National Health and Medical Research Council (NHMRC) grants 10275598 and 1038399.